3 ms·
Except there's a lot of studies showing CD8+ T-cell generation from inactivated coronavirus vaccines: https://www.frontiersin.org/articles/10.3389/fimmu.2021.7
by lamontcg 4y ago
Except there's a lot of studies showing CD8+ T-cell generation from inactivated coronavirus vaccines:
https://www.frontiersin.org/articles/10.3389/fimmu.2021.766278/full https://www.frontiersin.org/articles/10.3389/fimmu.2021.7662...
https://onlinelibrary.wiley.com/doi/10.1111/resp.14191 https://onlinelibrary.wiley.com/doi/10.1111/resp.14191
https://www.sciencedirect.com/science/article/pii/S1198743X21006054 https://www.sciencedirect.com/science/article/pii/S1198743X2...
The dendritic cells which take up the inactivated virus vaccine will chop up the structural and spike proteins and display that on host MHC for T-cells and B-cells in germinal centers. The T-cells don't know if the protein fragments come from foreign particles or cell synthesis. The happens in both mRNA vaccines and inactivated virus vaccines and both require cross-presentation by the dendritic cells.