2 ms·
Not a solid study for at least five distinct reasons: 1. The lifespan of both control and treated mice (C57BL/6N) is very significantly less than all other stu
by robwwilliams 4y ago
Not a solid study for at least five distinct reasons:
1. The lifespan of both control and treated mice (C57BL/6N) is very significantly less than all other studies of which I am aware. See for example: https://phenome.jax.org/measures/23201 https://phenome.jax.org/measures/23201
by Yuan et al. In this study untreated B6 untreated B6 mice typically have a median lifespan of over 800+ days.
2. The phenotyping of animals was apparently not done blinded to treatment. This can introduce strong bias in data generation.
3. No completely untreated control. For all we know the iv injection every three weeks contributed to short lifespan snd perhaps albumin mitigated stress response.
4. No control for injection of other major serum proteins such as gelsolin. What evidence demonstrates selectivity of albumin? None.
5. This is again a study of a single inbred genome of mouse. N=1. While both sexes were studied, it would be great to see results replicated properly using genetically diverse UM-HET3 mice.