Try instead replacing some of the fat with sugar. It's all biological fact. Research Insulin, blood sugar, and Ghrelin. Insulin responds to high blood sugar

Try instead replacing some of the fat with sugar. It's all biological fact. Research Insulin, blood sugar, and Ghrelin. Insulin responds to high blood sugar levels and tells all your cells to take in the sugar. Ghrelin triggers when you eat fatty foods and tells you you're full. If you spike your blood sugar, then you spike your insulin, then your blood sugar crashes. The metric for that is glycemic load. None of this requires such a high level experiment as you've mentioned, but it could be done.