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Data from Hong Kong shows that three shots of Sinovac is still 98% effective against severe outcomes with Omicron: https://fortune.com/2022/03/22/china-covid-v

Data from Hong Kong shows that three shots of Sinovac is still 98% effective against severe outcomes with Omicron: https://fortune.com/2022/03/22/china-covid-vaccine-data-reopen-mrna-sinovac-biontech-efficacy-booster-third-dose-death/ https://fortune.com/2022/03/22/china-covid-vaccine-data-reop... And it doesn't make a lot of sense that the different vaccines would be substantially different against different variants or would wane quicker once the same level of vaccination was reached. Once you've got the T-cells and B-cells they're permanent and they aren't going to remember what kind of vaccine they came from. The differences in the vaccines should just be in overall effectiveness. Mostly they just need to get their elderly population vaccinated, doesn't matter much how. It is really weird to watch China treat them with kid gloves.

twic 4y ago
> And it doesn't make a lot of sense that the different vaccines would be substantially different against different variants or would wane quicker once the same level of vaccination was reached. Once you've got the T-cells and B-cells they're permanent and they aren't going to remember what kind of vaccine they came from. The differences in the vaccines should just be in overall effectiveness. Not quite. Subunit (Novavax) or inactivated virus vaccines (like the Chinese ones) do not cause synthesis of viral proteins, so they do not stimulate killer T cell immunity [1]. That's a whole arm of the immune system which is not getting primed. [1] Except to a limited extent via cross-presentation, i know
- lamontcg 4y ago
  Except there's a lot of studies showing CD8+ T-cell generation from inactivated coronavirus vaccines: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766278/full https://www.frontiersin.org/articles/10.3389/fimmu.2021.7662... https://onlinelibrary.wiley.com/doi/10.1111/resp.14191 https://onlinelibrary.wiley.com/doi/10.1111/resp.14191 https://www.sciencedirect.com/science/article/pii/S1198743X21006054 https://www.sciencedirect.com/science/article/pii/S1198743X2... The dendritic cells which take up the inactivated virus vaccine will chop up the structural and spike proteins and display that on host MHC for T-cells and B-cells in germinal centers. The T-cells don't know if the protein fragments come from foreign particles or cell synthesis. The happens in both mRNA vaccines and inactivated virus vaccines and both require cross-presentation by the dendritic cells.

twic 4y ago

> And it doesn't make a lot of sense that the different vaccines would be substantially different against different variants or would wane quicker once the same level of vaccination was reached. Once you've got the T-cells and B-cells they're permanent and they aren't going to remember what kind of vaccine they came from. The differences in the vaccines should just be in overall effectiveness. Not quite. Subunit (Novavax) or inactivated virus vaccines (like the Chinese ones) do not cause synthesis of viral proteins, so they do not stimulate killer T cell immunity [1]. That's a whole arm of the immune system which is not getting primed. [1] Except to a limited extent via cross-presentation, i know

lamontcg 4y ago
Except there's a lot of studies showing CD8+ T-cell generation from inactivated coronavirus vaccines: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766278/full https://www.frontiersin.org/articles/10.3389/fimmu.2021.7662... https://onlinelibrary.wiley.com/doi/10.1111/resp.14191 https://onlinelibrary.wiley.com/doi/10.1111/resp.14191 https://www.sciencedirect.com/science/article/pii/S1198743X21006054 https://www.sciencedirect.com/science/article/pii/S1198743X2... The dendritic cells which take up the inactivated virus vaccine will chop up the structural and spike proteins and display that on host MHC for T-cells and B-cells in germinal centers. The T-cells don't know if the protein fragments come from foreign particles or cell synthesis. The happens in both mRNA vaccines and inactivated virus vaccines and both require cross-presentation by the dendritic cells.