3 ms·
Not a doctor, but a PhD with some work on protein pharmacokinetics. Serum albumin and antibodies are the two longest lived proteins in your blood because we hav
by ramraj07 4y ago
Not a doctor, but a PhD with some work on protein pharmacokinetics. Serum albumin and antibodies are the two longest lived proteins in your blood because we have special mechanisms and proteins to salvage them from where other proteins get degraded. That’s why their half life in blood is in months. They’re also (unless you make them targeted) benign in many ways (hence IVIG is used fairly indiscriminately). Thus, of all the longevity related therapy ideas, this seems the most benign. And makes a little bit of sense too, though further mechanism studies are needed (which are always hard).
If Peter Thiel or some other longevity obsessed techidiot is reading this though, don’t go around injecting albumin into yourself yet - and don’t talk to quack doctors obsessed with longevity either. What I’ve learned time and again is you always think Ying and your body’s biology will come and Yang you in the kidney.
- inglor_cz 4y agoSeeing an expert here, I have a question. What about misfolded albumin, is that a (significant) thing? Does the fraction of misfolded albumin increase significantly with aging?
- ramraj07 4y agoI did a quick google since I’ve never heard of misfolded albumin in the serum before and didn’t find anything.. are you asking from any prior research or discussions? Just from my knowledge I’d be surprised if there’s any amount of misfolded protein in the blood stream - every protein molecule in the blood stream needs to be actively salvaged (in your kidneys and macrophages) from degradation and this salvation is provided through their binding to receptors. If albumin is misfolded it should be cleared out quite fast. Note this is why antibody based drugs are more popular now - you get month long half lives for free.
- inglor_cz 4y agoIt is something that emerged in the longevity subreddit some time ago.
- netizen-936824 4y agoWere those discussions about proteins in general misfolding or specifically serum albumin? This is an important distinction, many conversations I've overheard from those not in a bio field seem to gloss over vital details
- inglor_cz 4y agoSpecifically albumin, which surprised me a bit back then, but admittedly I do not know nearly enough about proteins to be validly surprised.
- icoder 4y agoPeter Thiel or Peter Attia?
- ramraj07 4y agoThe former allegedly injects himself with young people blood so him.
- kikoreis 4y agoYes? No? Maybe? - https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to-inject-himself-with-young-peoples-blood https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to... - https://techcrunch.com/2017/06/14/no-peter-thiel-is-not-harvesting-the-blood-of-the-young/ https://techcrunch.com/2017/06/14/no-peter-thiel-is-not-harv... - https://gizmodo.com/someone-is-trying-to-discredit-the-story-of-peter-thiel-1796135794 https://gizmodo.com/someone-is-trying-to-discredit-the-story... - https://www.independent.co.uk/tech/peter-thiel-vampire-donald-trump-life-extension-blood-transfusion-ambrosia-palantir-a8614061.html https://www.independent.co.uk/tech/peter-thiel-vampire-donal...
- ramraj07 4y agoAnd that’s why I used the word allegedly.