5 ms·

picamilon is banned? That's dumb, soon they will ban l-theanine and taurine? I really don't think you can get addicted to picamillon like phen or benz

heavyset_go 4y ago
The FDA's argument is that it isn't a naturally occurring substance like an amino acid: https://en.wikipedia.org/wiki/Picamilon#Regulation https://en.wikipedia.org/wiki/Picamilon#Regulation
- SemanticStrengh 4y ago
  insane hypocrisy from the Federal Death Agency, a prodrug is functionally the exact same thing as the endogenously occuring substance
  - heavyset_go 4y ago
    I agree. I tried picamilon in the past, it's a very benign substance. Never experienced withdrawals or dependence. It's not like it's an exogenous GABA ligand or modulator, either. I'd venture to say that if any GABA actually makes it to the brain, it's just recycled via reuptake into pre/post-synaptic clefts, whereas phenibut and benzodiazepines cause increased binding of existing GABA, and in their absence, can cause dependence when GABA receptors return to their natural binding states. edit: apparently phenibut directly binds to GABA receptors, which is different than how benzodiazepines work. It also acts like gabapentin.
kayodelycaon 4y ago
Some supplements are basically unregulated medications. I found out the hard way that L-Theanine does not mix well with bipolar disorder. I suspect it inactivated the mood stabilizer I was on.
- SemanticStrengh 4y ago
  that is surprising to hear. ltheanine action of GABA should calm/stabilize you. it's action of dopamine might trigger anxiety/anger/mania but the effect is so mild vs caffeine/nicotine/amphetamine that I find it surprising/weird. To be clear we are talking about theanine and not theine.
  - kayodelycaon 4y ago
    Both Lamotrigine (anticonvulsant) and L-Theanine act on glutamate. Mixing them was a bad, bad idea. I don’t think I slept more than 2 hours a day most of March. (My psychiatrist was not happy.)
- rejectfinite 4y ago
  Maybe dont mix shit if you already have fucking BIPOLAR! Let us that are normal and know what we are doing keep our drugs. Yes, caffeine and l-theamine are drugs.

heavyset_go 4y ago

The FDA's argument is that it isn't a naturally occurring substance like an amino acid: https://en.wikipedia.org/wiki/Picamilon#Regulation https://en.wikipedia.org/wiki/Picamilon#Regulation

SemanticStrengh 4y ago
insane hypocrisy from the Federal Death Agency, a prodrug is functionally the exact same thing as the endogenously occuring substance
- heavyset_go 4y ago
  I agree. I tried picamilon in the past, it's a very benign substance. Never experienced withdrawals or dependence. It's not like it's an exogenous GABA ligand or modulator, either. I'd venture to say that if any GABA actually makes it to the brain, it's just recycled via reuptake into pre/post-synaptic clefts, whereas phenibut and benzodiazepines cause increased binding of existing GABA, and in their absence, can cause dependence when GABA receptors return to their natural binding states. edit: apparently phenibut directly binds to GABA receptors, which is different than how benzodiazepines work. It also acts like gabapentin.

kayodelycaon 4y ago

Some supplements are basically unregulated medications. I found out the hard way that L-Theanine does not mix well with bipolar disorder. I suspect it inactivated the mood stabilizer I was on.

SemanticStrengh 4y ago
that is surprising to hear. ltheanine action of GABA should calm/stabilize you. it's action of dopamine might trigger anxiety/anger/mania but the effect is so mild vs caffeine/nicotine/amphetamine that I find it surprising/weird. To be clear we are talking about theanine and not theine.
- kayodelycaon 4y ago
  Both Lamotrigine (anticonvulsant) and L-Theanine act on glutamate. Mixing them was a bad, bad idea. I don’t think I slept more than 2 hours a day most of March. (My psychiatrist was not happy.)
rejectfinite 4y ago
Maybe dont mix shit if you already have fucking BIPOLAR! Let us that are normal and know what we are doing keep our drugs. Yes, caffeine and l-theamine are drugs.