yes yes I know that increasing CSF flow is not that novel (anymore e.g. last couple of years). you can increase it with cerebral blood flow, and you can do this

yes yes I know that increasing CSF flow is not that novel (anymore e.g. last couple of years). you can increase it with cerebral blood flow, and you can do this with sleep, respiration, visual stimuli, etc. however, the ideas of 1) replacing csf from young to older mice and 2) the idea that there are factors in CSF that are being delivered to other areas of the brain and promoting cell proliferation: that's pretty novel. all of the literature right now points to csf in terms of waste clearance and csf is painted as almost a river that picks up components and moves waste (e.g. amyloid beta) from the periarterial areas in the parenchyma and then out through the perivenous areas into the lymphatic system. and this means that the idea of delivery of promoting factors is really interesting.