5 ms·
Not a physician either. This is an interesting result and is deserving of being followed up. That being said, there are many acknowledged causes of SIDS so this
by abcc8 4y ago
Not a physician either. This is an interesting result and is deserving of being followed up. That being said, there are many acknowledged causes of SIDS so this biomarker is unlikely to end up being predictive (or correlated) with all causes of SIDS. As has been mentioned elsewhere in the tread, suffocation on objects within the crib was responsible for at least some cases.
What is interesting to me is that this is a biochemical marker and biochemical disorders are known causes of SIDS. Newborn screening, which varies from state to state, can catch many of these disorders. This result is interesting because it may lead to other studies that identify other pathways/enzymes that represent markers or causes of less common causes of SIDS.
MCAD deficiency, the most common inborn error in fatty acid oxidation, is a biochemical disorder that is one of the more common causes of SIDS. The infants simply run out of easily available fuel for their metabolism if untreated and can die during fasting (i.e. in their cot in the middle of the night). Giving starch or other complex carbs before bedtime is one of several treatments for this disease, with the overall goal of treatment to prevent the individual from entering a fasting state, as that is when they metabolically decompensate.