8 ms·
this above article is kind of inflammatory, however, this paper is incredibly interesting. I read it this morning and the concept of changing CSF in order to h
by ninesnines 4y ago
this above article is kind of inflammatory, however, this paper is incredibly interesting.
I read it this morning and the concept of changing CSF in order to have an increase in oligodendrocyte progenitor cell proliferation and differentiation is such a creative idea; a lot of the idea has focused on increasing flow in order to move waste, etc with csf. I think this concept that CSF is also acting as an important mechanism to moving factors that will cause up regulation, etc, is very novel.
honestly one of my favourite papers in the last five years, I am obsessed.
- mwint 4y agoI'm curious, what is your favorite paper of all time (the specification of 'last five years' sounds like it's not this one?)
- ninesnines 4y agoah there are a lot of really nice old nature/science neuroscience articles that are really clear! papers were more simple and clear 20 years ago
- SemanticStrengh 4y agoThe papers from the 90s are generally my favorites.
- SemanticStrengh 4y agoI don't have a favorite but one that stands out is the resuscitation of cryogenized hamsters https://royalsocietypublishing.org/doi/10.1098/rspb.1956.0053 https://royalsocietypublishing.org/doi/10.1098/rspb.1956.005...
- ninesnines 4y agoholy cinnamon I've never seen this -- brilliant
- s1artibartfast 4y agoModifying CSF turnover is not particularly novel, but I do think it is generally overlooked. CSF production cycling is greatly reduced in the elderly and and there are a lot of connections to memory diseases such as alzheimers. A few medical device startups have attacked the problem with promising results. Unfortunately, VC and national funding orgs aren't particularly interested in device based solutions because pills and injections are perpetually 5 years out. I'm aware of at least one that was able to halt or reverse alzheimers in a 200 patient trial, but folded after they couldnt get funding to move forward.
- SemanticStrengh 4y agoI remember seeing a drug/substance that potentiated the glymphatic system filtration but I just can't find it again, it's been a year..
- ninesnines 4y agosorry! maybe it's just my thoughts on the matter that have changed. i understand that you can have drugs move through the glymphatic system, but maybe i was just unaware that you can move a whole host of other cell proliferation factors through the glymphatic system also!
- SemanticStrengh 4y agoTo be clear I was talking about a drug that increase the fluid movement rate/duration/frequency of the glymphatic filtering, which allow to improve the quantity of cleaning. If you're talking about the effect of the glymphatic system on the repartition of Neurotrophics, I have no idea :)
- s1artibartfast 4y agoThere's a fair bit of literature suggesting that there's more to it than the production rate. Metabolite delivery and removal also depends on the dynamic pressure and frequency response of the system. That is to say, to get the appropriate pulsatile flow the brain can't be too rigid or too flaccid