4 ms·

My father was diagnosed 15 years ago and started showing signs as early as 2007. My grandfather and two of his brothers had Parkinson’s which nobody in the fami

by kylixz 4y ago

My father was diagnosed 15 years ago and started showing signs as early as 2007. My grandfather and two of his brothers had Parkinson’s which nobody in the family talked about. I am hoping to get genetic markers tested for myself and my son — though my understanding is they are not always directly correlated. The most surprising aspect of the disease to me has been the changes to personality and executive function. My father, a very independent, loving, and physically active individual now is unable to decide what he wants to eat every day or leave the house because of anxiety. It’s hard to watch and I hope for my family and others that soon there is a cure. If anyone has any suggestions for how to get someone to accept their diagnosis and try various methods of treatment, I would welcome their advice.

tbalsam 4y ago
Longecity always has stuff, lots of miss, some hits. Just was looking at the mitochondria protocols that have been refined over the past few years, pretty cool stuff, but even if that works it's only one tiny aspect of aging and degenerative diseases. A successful fission-fusion protocol should be able to bring the mitochondria population to a point where stem cell reserves are able to split in two perfect (nearly) copies, boosting stem cell reserves counts. Then you can use C60 (buckyballs, how it triggers this I do not know) to use stem cell reserves. There's a lot of pros, cons, finicky, armchair theorists, desperate people, really smart people, and principled experimenters all in a mix. Absolutely fascinating reading. But one onramp seems to be mitochondrial in origin, and the fission-fusion protocol... turnbuckle, I think it is? Seems to be pretty darn successful in individuals, especially older ones. Not sure if that helps at all obviously the classic well proven methods are best if you can, but if you're wanting to know down Aubrey DeGray's aging damage/etc list, this is a good onramp to cover a few of them. Very bleeding edge, and very cool stuff! The threads can take days to read but are worth every penny-second of that time.
- tbalsam 4y ago
  Oh, and there is some established stuff on Parkinson's, the destruction of dopaminergic neurons&etc, and other parts of the progression of the disease of Parkinson's out there. I'd recommend boning up on that too, if it's hereditary, it's good to know. Just get a DNA test that doesn't freaking sell your data cough cough. It's not terribly expensive for the potential upside and just worth knowing sooner rather than later whatcha got going on for that There's also doctors that look at genetic stuff purely now, I think? Not necessarily integrative, just purely genetics stuff. I have no idea about that, maybe that's helpful a tad!

by kylixz 4y ago

tbalsam 4y ago

Longecity always has stuff, lots of miss, some hits. Just was looking at the mitochondria protocols that have been refined over the past few years, pretty cool stuff, but even if that works it's only one tiny aspect of aging and degenerative diseases. A successful fission-fusion protocol should be able to bring the mitochondria population to a point where stem cell reserves are able to split in two perfect (nearly) copies, boosting stem cell reserves counts. Then you can use C60 (buckyballs, how it triggers this I do not know) to use stem cell reserves. There's a lot of pros, cons, finicky, armchair theorists, desperate people, really smart people, and principled experimenters all in a mix. Absolutely fascinating reading. But one onramp seems to be mitochondrial in origin, and the fission-fusion protocol... turnbuckle, I think it is? Seems to be pretty darn successful in individuals, especially older ones. Not sure if that helps at all obviously the classic well proven methods are best if you can, but if you're wanting to know down Aubrey DeGray's aging damage/etc list, this is a good onramp to cover a few of them. Very bleeding edge, and very cool stuff! The threads can take days to read but are worth every penny-second of that time.

tbalsam 4y ago
Oh, and there is some established stuff on Parkinson's, the destruction of dopaminergic neurons&etc, and other parts of the progression of the disease of Parkinson's out there. I'd recommend boning up on that too, if it's hereditary, it's good to know. Just get a DNA test that doesn't freaking sell your data cough cough. It's not terribly expensive for the potential upside and just worth knowing sooner rather than later whatcha got going on for that There's also doctors that look at genetic stuff purely now, I think? Not necessarily integrative, just purely genetics stuff. I have no idea about that, maybe that's helpful a tad!