4 ms·

As someone growing pawpaws, I'd be interested to know if this also holds for progressive supranuclear palsy.

SemanticStrengh 4y ago
Neurodegenerative diseases are in fact quite simple to partially address. As always oxidative stress and mitochondria bioenergetics are the critical factor in the chain leading to neural apoptosis. Anyone can get revolutionary results with e.g Skq1 which is precisely 1000000 times more potent than NAC because it exploit the negative charge of the mitochondria to be attracted to it. But even without taking of mitochondria targeted antioxidants there exist many potent mitoprotectors, see e.g the pictures of saved brain volume in this generic oxys rat simulation (accelerated Aging) https://www.researchgate.net/publication/221738761_Evaluation_of_Effects_of_Histochrome_and_Mexidol_on_Structural_and_Functional_Characteristics_of_the_Brain_in_Senescence-Accelerated_OXYS_Rats_by_Magnetic_Resonance_Imaging https://www.researchgate.net/publication/221738761_Evaluatio... As I often say, the times it takes for scientific knowledge to be used by practitioners is often infinity. In fact that is the general case. We will have to wait for more people to suffer and die because you know running clinical trials is such a 20th century thing
- Alex3917 4y ago
  Would Skq1 (or NAC) likely ameliorate mitochondrial damage when eating foods with acetogenins? This is the hypothesized mechanism of action: https://pubmed.ncbi.nlm.nih.gov/23180140/ https://pubmed.ncbi.nlm.nih.gov/23180140/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672878/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672878/ edit: I do see this suggesting that NAC would help, which is super interesting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/
  - tbalsam 4y ago
    I've been feet in the bio space for funsies for a while, this is one of the coolest protocols I've seen yet since it's relatively cheap, easy, and actually seems to have a pretty solid impact where stuff matches what's on the tin. I think both of y'all would appreciate it and would love to hear y'all's thoughts. Currently doing this now as I have some pretty bad metabolic issues and am sensitive to fission promoting substances with similar reactions to all. Take with a grain of salt, but remember you have to both have fusion and fission to clean up your mitochondrial pool, I think the details are in the thread. Then there's increasing counts, and demethylating the mtDNA. Not too hard if following a protocol is all you want, but this is seriously cool from a nerdy perspective. Can you imagine once yearly depot injections with slightly tweaked versions of these in 50 years for anti-aging? That would be so sick. Anyways, here's the thread here: https://www.reddit.com/r/sleephackers/comments/ohfetn/turnbuckle_longecity_mitochondrial_fissionfusion/ https://www.reddit.com/r/sleephackers/comments/ohfetn/turnbu...

Neurodegenerative diseases are in fact quite simple to partially address. As always oxidative stress and mitochondria bioenergetics are the critical factor in the chain leading to neural apoptosis. Anyone can get revolutionary results with e.g Skq1 which is precisely 1000000 times more potent than NAC because it exploit the negative charge of the mitochondria to be attracted to it. But even without taking of mitochondria targeted antioxidants there exist many potent mitoprotectors, see e.g the pictures of saved brain volume in this generic oxys rat simulation (accelerated Aging) https://www.researchgate.net/publication/221738761_Evaluation_of_Effects_of_Histochrome_and_Mexidol_on_Structural_and_Functional_Characteristics_of_the_Brain_in_Senescence-Accelerated_OXYS_Rats_by_Magnetic_Resonance_Imaging https://www.researchgate.net/publication/221738761_Evaluatio... As I often say, the times it takes for scientific knowledge to be used by practitioners is often infinity. In fact that is the general case. We will have to wait for more people to suffer and die because you know running clinical trials is such a 20th century thing

Alex3917 4y ago
Would Skq1 (or NAC) likely ameliorate mitochondrial damage when eating foods with acetogenins? This is the hypothesized mechanism of action: https://pubmed.ncbi.nlm.nih.gov/23180140/ https://pubmed.ncbi.nlm.nih.gov/23180140/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672878/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672878/ edit: I do see this suggesting that NAC would help, which is super interesting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379763/
- tbalsam 4y ago
  I've been feet in the bio space for funsies for a while, this is one of the coolest protocols I've seen yet since it's relatively cheap, easy, and actually seems to have a pretty solid impact where stuff matches what's on the tin. I think both of y'all would appreciate it and would love to hear y'all's thoughts. Currently doing this now as I have some pretty bad metabolic issues and am sensitive to fission promoting substances with similar reactions to all. Take with a grain of salt, but remember you have to both have fusion and fission to clean up your mitochondrial pool, I think the details are in the thread. Then there's increasing counts, and demethylating the mtDNA. Not too hard if following a protocol is all you want, but this is seriously cool from a nerdy perspective. Can you imagine once yearly depot injections with slightly tweaked versions of these in 50 years for anti-aging? That would be so sick. Anyways, here's the thread here: https://www.reddit.com/r/sleephackers/comments/ohfetn/turnbuckle_longecity_mitochondrial_fissionfusion/ https://www.reddit.com/r/sleephackers/comments/ohfetn/turnbu...