Fullstack dev here with more experience in front-end. I struggle too. I'll tried a lot of different things (ex : puppeteer vs cypress, react vs angular2), and

Fullstack dev here with more experience in front-end. I struggle too. I'll tried a lot of different things (ex : puppeteer vs cypress, react vs angular2), and I end up having my own preference. I'll try to answer some of your questions : - Should I use SPA ? Slower initial page loading time, but faster to load more pages. Good if typical user stay long on website and navigate multiple pages. - Es6 import ? Use them when you can, better IDE support than require. - Build tool ? Start with webpack, oldest tool, with more chance to find answer to your questions on stackoverflow. Although I have little experience on the others (Rollup, etc), so maybe there is one that is simpler to start with. - React or Vue ? Idk, haven't used view, both are popular and similar, take one you prefer the syntax ? - Something simpler ? Well, there is too much choice... Vanilla js, another cool library, low code or no code like wordpress... - SSR ? Less API to build. Faster initial page loading. Roughly. There is quite a lot of library out there with SSR, and it is elvolving quite fast. The future is probably a mix of server and client side rendering. - npm vs yarn ? I recently played with npm workspaces, and yarn had a feature I needed, otherwise I think sticking to npm is fine. Historically yarn became popular because it introduced .lock file before npm. Npm has since catch up. - Css compiler ? Minifying, or compiling sass ? You can start without it. Also starter like "create react app" already do these optimizations for you. - Typescript ? Use it ! Only exception would be your code is too simple to take advantage of typing.