3 ms·

Alcohol too. And both tough on the liver, mere coincidence I suppose.

by x-shadowban 4y ago

noduerme 4y ago
As a drinker, I stick to ibuprofen. I wonder if it's as good for social pain.
- cassepipe 4y ago
  I wonder if that's not also bad for your liver. Ifnyiu take if for the hangover, I really recommend drinking a lot of water before going to bed instead, it makes wonders.
  - rrrrrrrrrrrryan 4y ago
    It isn't just about being "bad for your liver" - combining alcohol and acetaminophen can literally kill you. If you've drank enough over the years to permanently damage your liver, there are ton of medications you can no longer take (and ibuprofen is one of them), but if your liver is still working properly, taking ibuprofen is safe - even with alcohol.
  - noduerme 4y ago
    No, I try to not get hung-over enough to need analgesics. But I have persistent back problems, and taking Tylenol for it regularly would probably cause some compounding liver damage. Ibuprofen is, fwiw, much harder on the stomach - but not toxic to the liver. That's why it's the go-to-side-dish for alkies with a breakfast burrito.
  - smegsicle 4y ago
    > drinking a lot of water and b vitamins (b12 seems to have the greatest effect on reducing hangovers, and i've heard alcoholics tend to be b6 deficient so can't go wrong w that too)
    - noduerme 4y ago
      B12 is indeed a hangover cure. In Las Vegas, there are food truck style vans that drive down the Strip in the morning and give people B12 injections. In Australia there's a dissolvable seltzer tablet called Berocca (made by Bayer) which everyone takes the night they're getting drunk. For some reason, the same Berocca tablets in America have less vitamin-B, and include ginseng, and are twice as expensive as they are Down Under. But in America there's a thing called "Emergen-C" which while not marketed as a hangover medicine has almost the exact same B6/12 and C proportions as Berocca in Australia. I figured this out after awhile when my band's drummer kept "smuggling" Australian Berocca back to the States for us. Which just shows it does work, a little.
Trouble_007 4y ago
FYI: Acetaminophen a.k.a. Paracetamol N-acetyl-para-aminophenol (APAP) : https://en.wikipedia.org/wiki/Paracetamol https://en.wikipedia.org/wiki/Paracetamol Ethanol (Ethyl Alcohol) : https://en.m.wikipedia.org/wiki/Ethanol https://en.m.wikipedia.org/wiki/Ethanol Cytochrome P450 (Metabolism) : https://en.m.wikipedia.org/wiki/Cytochrome_P450 https://en.m.wikipedia.org/wiki/Cytochrome_P450 search: >list:'Cytochrome P450 Interaction'< @DDG : <https://html.duckduckgo.com/html/?q=list:'Cytochrome P450 Interaction' https://html.duckduckgo.com/html/?q=list:'Cytochrome P450 In...> search: >scholar:'Acetaminophen (N-acetyl-para-aminophenol, Paracetamol, APAP) Toxicity'< @DDG : <https://html.duckduckgo.com/html/?q=scholar:'Acetaminophen (N-acetyl-para-aminophenol, Paracetamol, APAP) Toxicity' https://html.duckduckgo.com/html/?q=scholar:'Acetaminophen (...>
mjan22640 4y ago
Alcohol damage of liver is indirect. The blood from intestine containig absorbed nutrients and whatever else got into it goes to liver first for the first line processing and neutralization. Alcohol loosens the intestine epithelium and lets the gut microbiome to get into the blood. This causes an inflamation, which if is chronic leads to the liver disease.

Alcohol too. And both tough on the liver, mere coincidence I suppose.

noduerme 4y ago

As a drinker, I stick to ibuprofen. I wonder if it's as good for social pain.

cassepipe 4y ago
I wonder if that's not also bad for your liver. Ifnyiu take if for the hangover, I really recommend drinking a lot of water before going to bed instead, it makes wonders.
- rrrrrrrrrrrryan 4y ago
  It isn't just about being "bad for your liver" - combining alcohol and acetaminophen can literally kill you. If you've drank enough over the years to permanently damage your liver, there are ton of medications you can no longer take (and ibuprofen is one of them), but if your liver is still working properly, taking ibuprofen is safe - even with alcohol.
- noduerme 4y ago
  No, I try to not get hung-over enough to need analgesics. But I have persistent back problems, and taking Tylenol for it regularly would probably cause some compounding liver damage. Ibuprofen is, fwiw, much harder on the stomach - but not toxic to the liver. That's why it's the go-to-side-dish for alkies with a breakfast burrito.
- smegsicle 4y ago
  > drinking a lot of water and b vitamins (b12 seems to have the greatest effect on reducing hangovers, and i've heard alcoholics tend to be b6 deficient so can't go wrong w that too)
  - noduerme 4y ago
    B12 is indeed a hangover cure. In Las Vegas, there are food truck style vans that drive down the Strip in the morning and give people B12 injections. In Australia there's a dissolvable seltzer tablet called Berocca (made by Bayer) which everyone takes the night they're getting drunk. For some reason, the same Berocca tablets in America have less vitamin-B, and include ginseng, and are twice as expensive as they are Down Under. But in America there's a thing called "Emergen-C" which while not marketed as a hangover medicine has almost the exact same B6/12 and C proportions as Berocca in Australia. I figured this out after awhile when my band's drummer kept "smuggling" Australian Berocca back to the States for us. Which just shows it does work, a little.

Trouble_007 4y ago

FYI: Acetaminophen a.k.a. Paracetamol N-acetyl-para-aminophenol (APAP) : https://en.wikipedia.org/wiki/Paracetamol https://en.wikipedia.org/wiki/Paracetamol Ethanol (Ethyl Alcohol) : https://en.m.wikipedia.org/wiki/Ethanol https://en.m.wikipedia.org/wiki/Ethanol Cytochrome P450 (Metabolism) : https://en.m.wikipedia.org/wiki/Cytochrome_P450 https://en.m.wikipedia.org/wiki/Cytochrome_P450 search: >list:'Cytochrome P450 Interaction'< @DDG : <https://html.duckduckgo.com/html/?q=list:'Cytochrome P450 Interaction' https://html.duckduckgo.com/html/?q=list:'Cytochrome P450 In...> search: >scholar:'Acetaminophen (N-acetyl-para-aminophenol, Paracetamol, APAP) Toxicity'< @DDG : <https://html.duckduckgo.com/html/?q=scholar:'Acetaminophen (N-acetyl-para-aminophenol, Paracetamol, APAP) Toxicity' https://html.duckduckgo.com/html/?q=scholar:'Acetaminophen (...>

mjan22640 4y ago

Alcohol damage of liver is indirect. The blood from intestine containig absorbed nutrients and whatever else got into it goes to liver first for the first line processing and neutralization. Alcohol loosens the intestine epithelium and lets the gut microbiome to get into the blood. This causes an inflamation, which if is chronic leads to the liver disease.