3 ms·
It's been long known that NMDA receptor antagonists worked this way, I've been using DXM for its antidepressant properties for years. I take 20mg nightly before
by gavinray 4y ago
It's been long known that NMDA receptor antagonists worked this way, I've been using DXM for its antidepressant properties for years. I take 20mg nightly before bed.
Another nifty property of it is that it reduces tolerance to other substances, like caffeine. Something about calcium ions that are usually released in response to neurotransmitters, as a mechanism to cause downregulation for homeostasis -- and DXM + other NDMA antagonists blocking them.
IANAD though.
- rubatuga 4y agoDXM is really good for resetting opioid tolerance, at least from personal experience.
- melissalobos 4y ago> it reduces tolerance to other substances, like caffeine Would this help at all with withdrawal symptoms as well? I don't know anything about biochemistry so that may be a very stupid question.
- gavinray 4y agoIt depends on what you're withdrawing from If you're withdrawing from opiates for example, your best (legal) bet is to buy some Kratom online, or pick up Immodium from your local drugstore. Immodium is a weak opiate that doesn't cross the blood-brain barrier -- so it'll alleviate withdrawal symptoms, but doesn't have psychoactive effects. If you're withdrawing from stimulants, the best thing you could get is probably Clonidine or Gabapentin, but neither of those are OTC unfortunately. It certainly won't hurt to take DXM if you're having WD/s, regardless of the substance though.
- ineedasername 4y agoI also found limited studies about it helping alcohol withdrawal, but they seemed very small, unblinded, and inconclusive.
- ineedasername 4y agoInteresting, was it refractory depression that resisted other treatments, or did DXM simply seem the least bad option?