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Title shortened to fit 80 char. There are a few clinical trials underway [1] Before anyone gets any ideas, OTC this stuff is often mixed with acetaminophen wh

Title shortened to fit 80 char. There are a few clinical trials underway [1] Before anyone gets any ideas, OTC this stuff is often mixed with acetaminophen which is can be very bad for the liver, and DMX itself may have adverse impacts on the kidneys. Don't go gulping this stuff down. But if the trials pan out it would be incredible to have a rapid efficacy drug along the lines of ketamine that is safe enough that it's put in OTC meds. Ketamine unfortunately has both a stigma and lower safety profile. [1] https://clinicaltrials.gov/ct2/show/NCT05181527 https://clinicaltrials.gov/ct2/show/NCT05181527

jamal-kumar 5y ago
X Gon' Give It To Ya [1] [1] https://www.youtube.com/watch?v=fGx6K90TmCI https://www.youtube.com/watch?v=fGx6K90TmCI
- justbaker 5y ago
  Laughing so much right now.
- ineedasername 5y ago
  Ah, transposition error. Oh well, I stand by the typo: 4 out of 5 leading Doctor Dre's agree that DMX is bad for your kidneys.
  - jamal-kumar 5y ago
    DXM on the other hand, as a less funny matter of fact, regularly makes people do stuff like shit their pants and/or die if they combine it with the wrong stuff like maybe a bit of booze. I don't know why people think it's somehow safer. It hits so many receptor sites and interacts with so many other drugs in the brain/liver, ketamine is not a dirty drug in that regard. I think this puts restrictions on its comparative therapeutic use. [1] [1] https://en.wikipedia.org/wiki/Dirty_drug https://en.wikipedia.org/wiki/Dirty_drug
    - ineedasername 5y ago
      Yes, and it's also an SRI so mixing with other medications, specifically SSRI's or SNRI's has significant negative risks of potentiation that could cause serotonin syndrome. Ketamine however is pretty hard on the kidneys, and its LD50 is significantly closer to therapeutic levels than DXM. Some quick searching shows it to be about 20x the dose used for depression while DXM, near as I can tell checking out a few sources that didn't always agree, has an LD50 roughly 100x higher than therapeutic doses. That doesn't mean it can't do other bad things to you (it can) but it's got a much more forgiving margin of error on acute toxicity. Most literature on severe overdoses mentions polydrug usage.

jamal-kumar 5y ago

X Gon' Give It To Ya [1] [1] https://www.youtube.com/watch?v=fGx6K90TmCI https://www.youtube.com/watch?v=fGx6K90TmCI

justbaker 5y ago
Laughing so much right now.
ineedasername 5y ago
Ah, transposition error. Oh well, I stand by the typo: 4 out of 5 leading Doctor Dre's agree that DMX is bad for your kidneys.
- jamal-kumar 5y ago
  DXM on the other hand, as a less funny matter of fact, regularly makes people do stuff like shit their pants and/or die if they combine it with the wrong stuff like maybe a bit of booze. I don't know why people think it's somehow safer. It hits so many receptor sites and interacts with so many other drugs in the brain/liver, ketamine is not a dirty drug in that regard. I think this puts restrictions on its comparative therapeutic use. [1] [1] https://en.wikipedia.org/wiki/Dirty_drug https://en.wikipedia.org/wiki/Dirty_drug
  - ineedasername 5y ago
    Yes, and it's also an SRI so mixing with other medications, specifically SSRI's or SNRI's has significant negative risks of potentiation that could cause serotonin syndrome. Ketamine however is pretty hard on the kidneys, and its LD50 is significantly closer to therapeutic levels than DXM. Some quick searching shows it to be about 20x the dose used for depression while DXM, near as I can tell checking out a few sources that didn't always agree, has an LD50 roughly 100x higher than therapeutic doses. That doesn't mean it can't do other bad things to you (it can) but it's got a much more forgiving margin of error on acute toxicity. Most literature on severe overdoses mentions polydrug usage.