27 ms·

I wish I knew someone that had a lot of knowledge of ALCAR. As someone that takes many different supplements, consumes no sugar, does IF, remains mostly keto+,

I wish I knew someone that had a lot of knowledge of ALCAR. As someone that takes many different supplements, consumes no sugar, does IF, remains mostly keto+, the one supplement I can't seem to take is ALCAR. It makes me feel "ill" for about 24 hours. It's hard to even describe the feeling. Just an overwhelming feeling that something is very wrong and generally just "feel like crap" for a day. I feel relief after a good full nights sleep which suggests to me that my brain is clearing the compound or a byproduct of it but that is just a theory.

SemanticStrengh 5y ago
Hmm that seems like a pretty rare side effects, at least I've never seen it reported on reddit. (Although some people have insomnia/palpitations which can be explained by e.g. TMAO) Maybe ALCAR makes your body consume not enough sugar but that seems unlikely. > that is just a theory well if you try to not sleep or only have a short night duration I think the result would be similar. The half life of ALCAR is ~17h so after 24h you no longer have a pharmacologically relevant dose, assuming you take as low as 500mg. BTW I recently discovered the organelle https://en.wikipedia.org/wiki/Peroxisome https://en.wikipedia.org/wiki/Peroxisome which is actually important in lipid (and therefore glucose) and oxidative metabolism
- LinuxBender 5y ago
  The glucose theory may be a good one to test out. I consume almost no glucose in my diet and I take several supplements that effectively also reduce gluconeogenesis. I also use Berberine. I will try a few different methods to boost either glucose or ketones in the brain prior to experimenting with ALCAR again.
  - SemanticStrengh 5y ago
    > several supplements that effectively also reduce gluconeogenesis: names? Also did you know that Berberine is the only drug (along with another exception) that significantly slow myopia progression? effect of ALCAR on brain-glucose: https://pubmed.ncbi.nlm.nih.gov/22549035/ https://pubmed.ncbi.nlm.nih.gov/22549035/

SemanticStrengh 5y ago

Hmm that seems like a pretty rare side effects, at least I've never seen it reported on reddit. (Although some people have insomnia/palpitations which can be explained by e.g. TMAO) Maybe ALCAR makes your body consume not enough sugar but that seems unlikely. > that is just a theory well if you try to not sleep or only have a short night duration I think the result would be similar. The half life of ALCAR is ~17h so after 24h you no longer have a pharmacologically relevant dose, assuming you take as low as 500mg. BTW I recently discovered the organelle https://en.wikipedia.org/wiki/Peroxisome https://en.wikipedia.org/wiki/Peroxisome which is actually important in lipid (and therefore glucose) and oxidative metabolism

LinuxBender 5y ago
The glucose theory may be a good one to test out. I consume almost no glucose in my diet and I take several supplements that effectively also reduce gluconeogenesis. I also use Berberine. I will try a few different methods to boost either glucose or ketones in the brain prior to experimenting with ALCAR again.
- SemanticStrengh 5y ago
  > several supplements that effectively also reduce gluconeogenesis: names? Also did you know that Berberine is the only drug (along with another exception) that significantly slow myopia progression? effect of ALCAR on brain-glucose: https://pubmed.ncbi.nlm.nih.gov/22549035/ https://pubmed.ncbi.nlm.nih.gov/22549035/