Single Cell RNA Seq data is often stored in Loom which is a HDF5 format. https://linnarssonlab.org/loompy/ https://linnarssonlab.org/loompy/ Its a little weir

Single Cell RNA Seq data is often stored in Loom which is a HDF5 format. https://linnarssonlab.org/loompy/ https://linnarssonlab.org/loompy/ Its a little weird at first but its a great format and has libraries in a lot of major languages. It stores a sparse matrix which cuts the size down a lot. https://linnarssonlab.org/loompy/format/index.html https://linnarssonlab.org/loompy/format/index.html