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Basically the ratio can be altered and it is very unclear if preferentially consuming lipids vs glucose is healthier than the converse. ALCAR shift said ratio t
by SemanticStrengh 4y ago
Basically the ratio can be altered and it is very unclear if preferentially consuming lipids vs glucose is healthier than the converse.
ALCAR shift said ratio towards pro lipids consumptions, which increase beta-oxidation. Thus it increase a kind of oxidative stress however in most studies it seems to both improve mitochondria bioenergetics and to reduce oxidative stress.
ALCAR improve many aspects of health and conditions in a potent way while having no acute nefast side effects.
You should see on reddit (e.g. sirsadalot), ALCAR is a very popular supplement and I was hyped like others because of the scientific evidence.
Very few people know it but there exist a ~direct opposite to ALCAR: https://en.wikipedia.org/wiki/Meldonium#Physio-pharmacology https://en.wikipedia.org/wiki/Meldonium#Physio-pharmacology
This drug decrease beta-oxidation and increase the ratio of glucose consumption.
As you can see e.g. on the wikipedia page, the rethoric behind mildronate sounds too very positive except many of the statements pro ALCAR/Mildronate are contradictory, in direct opposition.
So either there is an explanatory factor that resolve the contradictions, either one or the other do actually significant harm, despite both having backing scientific evidence of improving health.
This topic is major since those are the most potent mechanics toward mitochondria bioenergetics regulation, which is a major way to improve your lifespan/healthspan and even cognition.
The issue is that the quality of the dicussion/research needed to elucidate those issues is above the level found on online forums and no paper directly address the question, so I am stuck in uncertainty.
- chillingeffect 4y agoNmn is generally said w b fast-mimicking. In me it leads to collagen generation, soft skin, much faster than fasting or hyper-green drinks. ...if that helps your question...
- LinuxBender 4y agoI wish I knew someone that had a lot of knowledge of ALCAR. As someone that takes many different supplements, consumes no sugar, does IF, remains mostly keto+, the one supplement I can't seem to take is ALCAR. It makes me feel "ill" for about 24 hours. It's hard to even describe the feeling. Just an overwhelming feeling that something is very wrong and generally just "feel like crap" for a day. I feel relief after a good full nights sleep which suggests to me that my brain is clearing the compound or a byproduct of it but that is just a theory.
- SemanticStrengh 4y agoHmm that seems like a pretty rare side effects, at least I've never seen it reported on reddit. (Although some people have insomnia/palpitations which can be explained by e.g. TMAO) Maybe ALCAR makes your body consume not enough sugar but that seems unlikely. > that is just a theory well if you try to not sleep or only have a short night duration I think the result would be similar. The half life of ALCAR is ~17h so after 24h you no longer have a pharmacologically relevant dose, assuming you take as low as 500mg. BTW I recently discovered the organelle https://en.wikipedia.org/wiki/Peroxisome https://en.wikipedia.org/wiki/Peroxisome which is actually important in lipid (and therefore glucose) and oxidative metabolism
- LinuxBender 4y agoThe glucose theory may be a good one to test out. I consume almost no glucose in my diet and I take several supplements that effectively also reduce gluconeogenesis. I also use Berberine. I will try a few different methods to boost either glucose or ketones in the brain prior to experimenting with ALCAR again.
- SemanticStrengh 4y ago> several supplements that effectively also reduce gluconeogenesis: names? Also did you know that Berberine is the only drug (along with another exception) that significantly slow myopia progression? effect of ALCAR on brain-glucose: https://pubmed.ncbi.nlm.nih.gov/22549035/ https://pubmed.ncbi.nlm.nih.gov/22549035/