6 ms·

I’ve been taking flush niacin, which I believe has the same effect at a much lower cost. Flush is really only annoying the first day.

by rhexs 4y ago

Andys 4y ago
Flush niacin has been the only thing which has reliably improved my "long covid" symptoms.
- SemanticStrengh 4y ago
  You should consider doing a cycle of magnesium lthreonate for its potent synaptothrophic properties
- fnordpiglet 4y ago
  Try L Citruline. It easily passes the gut and readily converts to arginine which is a strong vasoprotector. Covid damages the lining of blood vessels. My belief is long covid is a redirection of free arginine to extensive vascular system damage and inflammation. At the minimum, it worked like a miracle for my long covid, YMMV. (Placebo possible of course, but citruline is used for body building as an energy and performance enhancer so the improvement in energy and thought clarity isn’t unexpected and has been shown to be beneficial in sickle cell which causes low free arginine due to the shape of the red cell irritating the lining of the blood vessels https://pubmed.ncbi.nlm.nih.gov/11688916/ https://pubmed.ncbi.nlm.nih.gov/11688916/)
  - dr_kiszonka 4y ago
    Were you taking 0.1 g/kg? How long was your treatment?
    - fnordpiglet 4y ago
      Yes. A few months but I felt results immediately, like within 30 minutes. I checked with my doctor first and she had no anxiety about trying it - she said any excess beyond what my body can manage would be immediately urinated out and citrulline is plentiful in the body.
      - dr_kiszonka 4y ago
        Thanks!
SemanticStrengh 4y ago
source on niacin flush having an action on mitochondria? Last time I checked the only study for its pro mood effect was from 1950 and the phenomenon was unexplained.
Geee 4y ago
You mean niacin, specifically? There's also the niacinamide (or nicotinamide) which doesn't cause flush. Both are Vitamin B3.
- nick__m 4y ago
  The pathway that trigger the release of prostaglandin is responsible for the dramatic effects niacin has on the lipid profile.[1] If you can't stand the sensation, you can block it by taking 200mg of ibuprofen 30min before taking niacin [2], but personally I love the feeling. I started taking niacin before doing push-ups when I read that it cause a 3 to 6 fold increase in growth hormone during exercise.[3] 1- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/ 2- same article page 14 to 15 3‐ https://pubmed.ncbi.nlm.nih.gov/7564973/ https://pubmed.ncbi.nlm.nih.gov/7564973/ edit: formatting

I’ve been taking flush niacin, which I believe has the same effect at a much lower cost. Flush is really only annoying the first day.

by rhexs 4y ago

I’ve been taking flush niacin, which I believe has the same effect at a much lower cost. Flush is really only annoying the first day.

Andys 4y ago

Flush niacin has been the only thing which has reliably improved my "long covid" symptoms.

SemanticStrengh 4y ago
You should consider doing a cycle of magnesium lthreonate for its potent synaptothrophic properties
fnordpiglet 4y ago
Try L Citruline. It easily passes the gut and readily converts to arginine which is a strong vasoprotector. Covid damages the lining of blood vessels. My belief is long covid is a redirection of free arginine to extensive vascular system damage and inflammation. At the minimum, it worked like a miracle for my long covid, YMMV. (Placebo possible of course, but citruline is used for body building as an energy and performance enhancer so the improvement in energy and thought clarity isn’t unexpected and has been shown to be beneficial in sickle cell which causes low free arginine due to the shape of the red cell irritating the lining of the blood vessels https://pubmed.ncbi.nlm.nih.gov/11688916/ https://pubmed.ncbi.nlm.nih.gov/11688916/)
- dr_kiszonka 4y ago
  Were you taking 0.1 g/kg? How long was your treatment?
  - fnordpiglet 4y ago
    Yes. A few months but I felt results immediately, like within 30 minutes. I checked with my doctor first and she had no anxiety about trying it - she said any excess beyond what my body can manage would be immediately urinated out and citrulline is plentiful in the body.
    - dr_kiszonka 4y ago
      Thanks!

SemanticStrengh 4y ago

source on niacin flush having an action on mitochondria? Last time I checked the only study for its pro mood effect was from 1950 and the phenomenon was unexplained.

Geee 4y ago

You mean niacin, specifically? There's also the niacinamide (or nicotinamide) which doesn't cause flush. Both are Vitamin B3.

nick__m 4y ago
The pathway that trigger the release of prostaglandin is responsible for the dramatic effects niacin has on the lipid profile.[1] If you can't stand the sensation, you can block it by taking 200mg of ibuprofen 30min before taking niacin [2], but personally I love the feeling. I started taking niacin before doing push-ups when I read that it cause a 3 to 6 fold increase in growth hormone during exercise.[3] 1- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/ 2- same article page 14 to 15 3‐ https://pubmed.ncbi.nlm.nih.gov/7564973/ https://pubmed.ncbi.nlm.nih.gov/7564973/ edit: formatting