4 ms·

Cellular Landscapes: Protein Synthesis

31 points by picture 4y ago

flobosg 4y ago
More information from one of the authors: https://gaelmcgill.artstation.com/projects/Pm0JL1 https://gaelmcgill.artstation.com/projects/Pm0JL1 > Created for Cell Signaling Technology, Inc., and inspired by the stunning art of David Goodsell[1], this 3D rendering of a eukaryotic cell is modeled using X-ray, nuclear magnetic resonance (NMR), and cryo-electron microscopy datasets for all of its molecular actors. It is an attempt to recapitulate the myriad pathways involved in signal transduction, protein synthesis, endocytosis, vesicular transport, cell-cell adhesion, apoptosis, and other processes. Although dilute in its concentration relative to a real cell, this rendering is also an attempt to visualize the great complexity and beauty of the cell’s molecular choreography. [1]: About David Goodsell – https://ccsb.scripps.edu/goodsell/ https://ccsb.scripps.edu/goodsell/
jimmySixDOF 4y ago
If you like this then there is an experience called Nanoscape [1][2] on the Steam game store (free) that was produced last June by an Australian university research group that basically places you at the center inside a real-time working cell modeled off high resolution electron microscopy with extremely rigorous attention to scientific detail. I am not a biologist, but getting a perspective from inside a lifelike full 3D model of the various interactions between Proteins, Receptors and the cell's Plasma Membrane is truly awe inspiring. There is a scientific paper that goes into all the details regarding folding and lipids and medical Maya software etc [3]- but I just think its an amazing way to appreciate the miracle of a thousand complexities that we are. [1] https://store.steampowered.com/app/1654050/Nanoscape/ https://store.steampowered.com/app/1654050/Nanoscape/ [2] https://store.steampowered.com/app/1634740/Nanoscape_VR/ https://store.steampowered.com/app/1634740/Nanoscape_VR/ [3] https://elifesciences.org/articles/64047 https://elifesciences.org/articles/64047
Kim_Bruning 4y ago
It's surprising how many people still think biology is somehow simpler than IT. This is very obviously not true. We're still just barely (not) capable of building or emulating the simplest biological systems. Each time some species goes extinct, you lose all of the information, inventions, concepts pertaining to super-sophisticated nanotech that were encoded in their DNA. The better we understand the value of diverse life forms, the more we will curse the people who let even one species go extinct on their watch.
- radarsat1 4y ago
  > It's surprising how many people still think biology is somehow simpler than IT. How many people? Is that an opinion you've actually come across in the wild? It would surprise me.
  - technobabble 4y ago
    As someone who used to work in a lab and was in the “biohacker” scene, yes.
  - ethbr0 4y ago
    It crops up in "Why don't they just..." type comments. The apt analogy is "Imagine you're debugging a 3.5 billion year old legacy codebase put together by copying and pasting."

31 points by picture 4y ago

More information from one of the authors: https://gaelmcgill.artstation.com/projects/Pm0JL1 https://gaelmcgill.artstation.com/projects/Pm0JL1 > Created for Cell Signaling Technology, Inc., and inspired by the stunning art of David Goodsell[1], this 3D rendering of a eukaryotic cell is modeled using X-ray, nuclear magnetic resonance (NMR), and cryo-electron microscopy datasets for all of its molecular actors. It is an attempt to recapitulate the myriad pathways involved in signal transduction, protein synthesis, endocytosis, vesicular transport, cell-cell adhesion, apoptosis, and other processes. Although dilute in its concentration relative to a real cell, this rendering is also an attempt to visualize the great complexity and beauty of the cell’s molecular choreography. [1]: About David Goodsell – https://ccsb.scripps.edu/goodsell/ https://ccsb.scripps.edu/goodsell/

jimmySixDOF 4y ago

If you like this then there is an experience called Nanoscape [1][2] on the Steam game store (free) that was produced last June by an Australian university research group that basically places you at the center inside a real-time working cell modeled off high resolution electron microscopy with extremely rigorous attention to scientific detail. I am not a biologist, but getting a perspective from inside a lifelike full 3D model of the various interactions between Proteins, Receptors and the cell's Plasma Membrane is truly awe inspiring. There is a scientific paper that goes into all the details regarding folding and lipids and medical Maya software etc [3]- but I just think its an amazing way to appreciate the miracle of a thousand complexities that we are. [1] https://store.steampowered.com/app/1654050/Nanoscape/ https://store.steampowered.com/app/1654050/Nanoscape/ [2] https://store.steampowered.com/app/1634740/Nanoscape_VR/ https://store.steampowered.com/app/1634740/Nanoscape_VR/ [3] https://elifesciences.org/articles/64047 https://elifesciences.org/articles/64047

Kim_Bruning 4y ago

It's surprising how many people still think biology is somehow simpler than IT. This is very obviously not true. We're still just barely (not) capable of building or emulating the simplest biological systems. Each time some species goes extinct, you lose all of the information, inventions, concepts pertaining to super-sophisticated nanotech that were encoded in their DNA. The better we understand the value of diverse life forms, the more we will curse the people who let even one species go extinct on their watch.

radarsat1 4y ago
> It's surprising how many people still think biology is somehow simpler than IT. How many people? Is that an opinion you've actually come across in the wild? It would surprise me.
- technobabble 4y ago
  As someone who used to work in a lab and was in the “biohacker” scene, yes.
- ethbr0 4y ago
  It crops up in "Why don't they just..." type comments. The apt analogy is "Imagine you're debugging a 3.5 billion year old legacy codebase put together by copying and pasting."