Depends on how well you know the tool. I wrote my lecture notes for Graph Theory in LaTeX+TikZ, but it only went well because I had been doing TikZ drawings fre

Depends on how well you know the tool. I wrote my lecture notes for Graph Theory in LaTeX+TikZ, but it only went well because I had been doing TikZ drawings frequently for about 2 years by that point, and also the course was introductory level, so the drawings were rather simple. For most other courses, we had a process involving at least two people, wherein one person would take notes in LaTeX with placeholders where the images need to go, and one person would take notes by hand, including images. Then we would produce the drawings either via TikZ or via Inkscape afterwards. This could be streamlined into one person doing LaTeX notes with placeholders, who also drew the images on paper to later insert them into the digital version.