6 ms·

I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy. Edit to reply because of comme

I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy. Edit to reply because of comment limit: Perhaps I misunderstood, but this example of rats on amphetamine doesn't say anything about any genetic defects.

SemanticStrengh 4y ago
ah yes almagaming people with recreational abuse from people with life changing medication that address genetic deficits. This is because of people like you adderall is not prescribed in many european countries.
- emteycz 4y ago
  I'm definitely not that reason as I'm one of the more loud supporters of it in my country. But this connection with the rat experiment is not something you want to use as an example of the benefits. The experiment shows that animals would rather absolutely destroy themselves than live without it, and they deteriorate during the experiment a lot too.
samtho 4y ago
> I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy. I’m betting you may know more people who take amphetamine in therapeutic doses than you think - assuming it or other medications that break down into amphetamine (vyvance) are legal to prescribe where you live. Methamphetamine is similar but very different in bioavailability and minimum effective dose (“methylation” is interesting but not relevant to go into here). It is largely believed that the ill effects of meth is primarily due to the garbage they cut it with before being sold on the street. Amphetamine is tolerated exceptionally well and is very safe at therapeutic doses and has been used as such for 80-some years. If there were major issues identified with it, we would have seen late night TV advertisements from law offices promising to get you a settlement if you or someone you know has used it. The truth is, this is one of the most effective medications we have in modern medicine with 70% of patients reporting major improvement to their lives when on the correct dose. The fact that it’s in schedule II in the US is a travesty given how many hoops one must jump through every month just to get a script filled especially considering it very effectively treats a disorder that makes following through with that stuff difficult.
- SemanticStrengh 4y ago
  Do you know wether methamph and methylphenidate as act pharmacologically relevant methyl donors, like SAM-e?
  - samtho 4y ago
    I’m afraid my knowledge is very limited on this and I’m not confident enough to even give an educated guess.

SemanticStrengh 4y ago

ah yes almagaming people with recreational abuse from people with life changing medication that address genetic deficits. This is because of people like you adderall is not prescribed in many european countries.

emteycz 4y ago
I'm definitely not that reason as I'm one of the more loud supporters of it in my country. But this connection with the rat experiment is not something you want to use as an example of the benefits. The experiment shows that animals would rather absolutely destroy themselves than live without it, and they deteriorate during the experiment a lot too.

samtho 4y ago

> I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy. I’m betting you may know more people who take amphetamine in therapeutic doses than you think - assuming it or other medications that break down into amphetamine (vyvance) are legal to prescribe where you live. Methamphetamine is similar but very different in bioavailability and minimum effective dose (“methylation” is interesting but not relevant to go into here). It is largely believed that the ill effects of meth is primarily due to the garbage they cut it with before being sold on the street. Amphetamine is tolerated exceptionally well and is very safe at therapeutic doses and has been used as such for 80-some years. If there were major issues identified with it, we would have seen late night TV advertisements from law offices promising to get you a settlement if you or someone you know has used it. The truth is, this is one of the most effective medications we have in modern medicine with 70% of patients reporting major improvement to their lives when on the correct dose. The fact that it’s in schedule II in the US is a travesty given how many hoops one must jump through every month just to get a script filled especially considering it very effectively treats a disorder that makes following through with that stuff difficult.

SemanticStrengh 4y ago
Do you know wether methamph and methylphenidate as act pharmacologically relevant methyl donors, like SAM-e?
- samtho 4y ago
  I’m afraid my knowledge is very limited on this and I’m not confident enough to even give an educated guess.