3 ms·
I would argue that, whatever “generation” it is, cetirizine does not deserve credit for being second generation. I know plenty of people with extremely obvious
by amluto 5y ago
I would argue that, whatever “generation” it is, cetirizine does not deserve credit for being second generation. I know plenty of people with extremely obvious CNS effects from it. In contrast, loratadine seems innocuous.
- tyrfing 5y agoFor me, loratadine was ineffective, and I can't distinguish cetirizine and fexofenadine - both are maybe 50-60% effective with no notable side effects, and allergy season means extra fatigue no matter what. Cetirizine does have the shortest half life.
- isoprophlex 5y agoSecond that, cetirizine definitely feels more like clemastine or meclizine than a proper second gen "non sedating" antihistamine. And with hay fever AND an allergy to nuts, I've tried them all, haha.
- imdvayn 5y agoUnfortunately its justifiably classified as 2nd gen and IIRC studies show that it's generally more effective for hay fever. Personally, I've found that loratadine is pretty ineffective, especially after regular use.
- jostmey 5y agoI found loratadine very effective but it takes time to work. At least a week
- _moof 5y agoCetirizine is a "no go" for pilots. Fexofenadine and loratadine are OK to fly on though, as is fluticasone.