If you play an F# then a C, does there not seem to be a "relationship" between the notes, that is different from if you play G then C? I think for most people i

If you play an F# then a C, does there not seem to be a "relationship" between the notes, that is different from if you play G then C? I think for most people it intuitively makes sense when they hear the notes. To me it sounds like F#->C is "awkward" whereas G->C is more "satisfying". Not sure if the explanation is in culture, neurology or physics or what, but to me an "emotional" relationship between the notes seem apparent on listening.