'Hacking' an intravenous drug to make it work as an oral drug: One key part of the chemists’ strategy was to eliminate some of the hydrogen bond donors that kee

'Hacking' an intravenous drug to make it work as an oral drug: One key part of the chemists’ strategy was to eliminate some of the hydrogen bond donors that keep PF-00835231 in the gut. If a particular hydrogen bond is critical to making the compound bind to the protease, it had to stay in the molecule. “We were looking for hydrogen bonds that we could get rid of without losing antiviral potency.”