4 ms·

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatli

An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level. So a ~flatline vs a sinusoid. It could be pharmacologically simulated.

hirundo 4y ago
Hormesis and the hygiene hypothesis suggest that "working out" can be good for the immune system too. Unfortunately variolation has become a difficult topic.
- The_rationalist 4y ago
  I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.
  - epgui 4y ago
    Exercise does trigger inflammation through a variety of mechanisms (eg.: increased tissue perfusion and diapedesis, oxidative stress, tissue damage...). However it also releases endocannabinoids, which are anti-inflammatory, and causes a host of metabolic changes which are also anti-inflammatory. The overall effect of exercise is to increase inflammation acutely, and to decrease it chronically. Regular physical exercise is overall more modulatory than inflammatory.
dashmeet 4y ago
Sounds like exercise or maybe a dry sauna would be a cost effective non pharmaceutical way, short term increase in inflammation that results in a long term decrease in inflammation. Same thing with injuries and fractures but that’s more unrelated.
epgui 4y ago
The basal inflammation level is in fact in large part periodic due to the cortisol cycle.
andreareina 4y ago
I don't think I've seen any serious suggestions that inflammation per se causes beneficial adaptations. Rather, <some activity> imposes a stress and the recovery/adaption process is mediated by inflammation, i.e. the why of the inflammation is important.
deleted 4y ago
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toshk 4y ago
Somewhat related to your idea, they seem to have some success with parasitic therapy with things like Crone. Introduce a "harmless" parasite (worm) and the body's immunesystem to trigger it. Not sure how long they keep it in the body, seems to be mostly for a longer time. https://en.wikipedia.org/wiki/Helminthic_therapy https://en.wikipedia.org/wiki/Helminthic_therapy

hirundo 4y ago

Hormesis and the hygiene hypothesis suggest that "working out" can be good for the immune system too. Unfortunately variolation has become a difficult topic.

The_rationalist 4y ago
I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.
- epgui 4y ago
  Exercise does trigger inflammation through a variety of mechanisms (eg.: increased tissue perfusion and diapedesis, oxidative stress, tissue damage...). However it also releases endocannabinoids, which are anti-inflammatory, and causes a host of metabolic changes which are also anti-inflammatory. The overall effect of exercise is to increase inflammation acutely, and to decrease it chronically. Regular physical exercise is overall more modulatory than inflammatory.

dashmeet 4y ago

Sounds like exercise or maybe a dry sauna would be a cost effective non pharmaceutical way, short term increase in inflammation that results in a long term decrease in inflammation. Same thing with injuries and fractures but that’s more unrelated.

epgui 4y ago

The basal inflammation level is in fact in large part periodic due to the cortisol cycle.

andreareina 4y ago

I don't think I've seen any serious suggestions that inflammation per se causes beneficial adaptations. Rather, <some activity> imposes a stress and the recovery/adaption process is mediated by inflammation, i.e. the why of the inflammation is important.

deleted 4y ago

[deleted]

toshk 4y ago

Somewhat related to your idea, they seem to have some success with parasitic therapy with things like Crone. Introduce a "harmless" parasite (worm) and the body's immunesystem to trigger it. Not sure how long they keep it in the body, seems to be mostly for a longer time. https://en.wikipedia.org/wiki/Helminthic_therapy https://en.wikipedia.org/wiki/Helminthic_therapy