Matlab: optimization and global optimization toolboxes. Python: PyOptSparse with IPOPT (and NSGA-II, although not the best implementation) and scipy.optimize.

Matlab: optimization and global optimization toolboxes. Python: PyOptSparse with IPOPT (and NSGA-II, although not the best implementation) and scipy.optimize. I use them for the Design Optimization of aircraft with multiple non-linear constraints and sometimes multiple objectives.