One thing to keep in mind when moving from sqlite to an "out-of-process" database is that individual query overhead will increase a lot. With sqlite it's usuall

One thing to keep in mind when moving from sqlite to an "out-of-process" database is that individual query overhead will increase a lot. With sqlite it's usually no problem to do lots of small queries and combine the result, but when you need to account for network latency etc it's a different game. This could be unintended; e.g. your ORM use causes lots of queries that you didn't know or care about with sqlite. You may have to rethink the way you do things in order to keep performance.