You can do it with LaTeX (using baposter or another template) and in my experience it worked well for the kind of things Beamer works well for - that is, text,

You can do it with LaTeX (using baposter or another template) and in my experience it worked well for the kind of things Beamer works well for - that is, text, equations, and simple images. Positioning and resizing things is as annoying as you’d think, but using something with an auto-updating preview (latexmk -pvc or Overleaf, etc) makes it a little more tolerable.