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I didn't downvote you but going from a structure prediction (which you get for ordered proteins) to functionality is not straightforward at all. How would you d
by paraschopra 5y ago
I didn't downvote you but going from a structure prediction (which you get for ordered proteins) to functionality is not straightforward at all. How would you do it?
You could predict functionality based on homology with evolutionary related sequences, but they would work equally well for all proteins (ordered or not).
- panabee 5y agothanks for replying. to clarify, the statement isn't that it is straightforward -- simply that it's easier to analyze something that doesn't change shape unpredictably than something that does (fewer variables to consider). whether predictions based on evolutionary related sequences are 100% accurate in human cells is another matter, especially when it comes to viruses.