That’s really interesting. I’m reminded of something the PhD Pharmacologist Psychiatrist told us during med school - effect size of new depression meds decreas

That’s really interesting. I’m reminded of something the PhD Pharmacologist Psychiatrist told us during med school - effect size of new depression meds decreases over time (probably because you have an early positive result and then it’s pushed in and then later better quality studies show smaller difference) so the joke is ‘every time a new depression medication comes out there’s a race to use it before it stops working!’