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if viral proteins are ordered, it becomes much easier to predict their functionality.
by panabee 5y ago
if viral proteins are ordered, it becomes much easier to predict their functionality.
- alan-hn 5y agoSo would the predictions be based entirely on the primary structure or assumed primary structure based on nucleotide sequence? Sounds to me like you're doing some bioinformatics stuff to understand how some virus works, or am I totally off base on that guess?
- panabee 5y agocorrect. if you downvoted the previous comment, would you mind sharing why? if ordered proteins are not in fact easier to understand than ID ones, it would be helpful to understand why. thanks for the feedback.
- panabee 5y agoinstead of only downvoting, could someone also clarify how this statement is wrong to help educate myself on the facts? thanks for your help.
- paraschopra 5y agoI didn't downvote you but going from a structure prediction (which you get for ordered proteins) to functionality is not straightforward at all. How would you do it? You could predict functionality based on homology with evolutionary related sequences, but they would work equally well for all proteins (ordered or not).
- panabee 5y agothanks for replying. to clarify, the statement isn't that it is straightforward -- simply that it's easier to analyze something that doesn't change shape unpredictably than something that does (fewer variables to consider). whether predictions based on evolutionary related sequences are 100% accurate in human cells is another matter, especially when it comes to viruses.