My own impression (and I've been intensely interested in both therapy and psychedelics for several decades) is that psychedelics in combination with therapy (an

My own impression (and I've been intensely interested in both therapy and psychedelics for several decades) is that psychedelics in combination with therapy (and sometimes even psychedelics alone) can be much more effective than therapy, antidepressants or their combination. A positive outcome from psychedelic therapy is not guaranteed. Some people don't benefit from it, but many more people benefit from it than other approaches. And when they do benefit, the benefit is often much more pronounced and also typically longer lasting. There's a lot of research on this, particularly on individuals with treatment-resistant depression. Psychedelic therapy is not a panacea.. and nothing that operates on your mind is going to magically fix the circumstances you're in or your relationships with others -- you have to do that yourself. But the depression itself can be helped.