>How do you do a placebo-controlled trial? I'd like to see a trial in which the participants are unconscious for the duration of the "trip". This would not onl

>How do you do a placebo-controlled trial? I'd like to see a trial in which the participants are unconscious for the duration of the "trip". This would not only be trivially blinded, but also help to establish whether the antidepressant effect stems entirely from the subjective experience, or whether there's a chemical component as well. People always say, "the trip is integral!". But we don't actually know that, do we?