"is there anything there that is fundamentally unchangeable no matter the chemistry that could be called a "self"" The Buddhists don't think so. One of their

"is there anything there that is fundamentally unchangeable no matter the chemistry that could be called a "self"" The Buddhists don't think so. One of their fundamental tenets is "anicca" or "impermanence", which is often interpreted to mean that nothing is unchangeable or everlasting. Many materialists/naturalists/physicalists don't believe there's an unchanging self either. But those who believe in a soul, in resurrection, or in reincarnation might. It's not a settled question, and a lot depends on what you mean by "self".