Many proteins have intrinsically disordered regions that are hypothesized to be directly related to the protein's role in the cell. These regions are termed dis

Many proteins have intrinsically disordered regions that are hypothesized to be directly related to the protein's role in the cell. These regions are termed disordered because current methods used to determine the structure of proteins are unable to resolve a regular structure for these regions in the context of a protein crystal or protein in solution. This publication is an informative review on the topic: https://pubs.acs.org/doi/10.1021/cr400525m https://pubs.acs.org/doi/10.1021/cr400525m