Active is a bad word to describe what I meant. I don't mean to say that a depressed mind is not thinking, just that it may not be able to get itself out of the

Active is a bad word to describe what I meant. I don't mean to say that a depressed mind is not thinking, just that it may not be able to get itself out of the place it is in without "active" effort (as in therapy - self-therapy or mediated by others). The conundrum is that putting in that effort may not possible because all energy is already spent - as you pointed out. My suggestion is that psychedelics opens space for these thoughts to be actively dealt with in a productive way. There is also mounting evidence that depression is a symptom and not a single disease, and the symptom may be originating from multiple causes. This view is supported by the extreme between-subject variability seen in imaging studies [1]. That being the case, maybe not all causes would require an "active" approach, just as maybe not all will respond to psychedelics. [1] https://www.nature.com/articles/s41386-020-00789-3 https://www.nature.com/articles/s41386-020-00789-3