5 ms·

I tripped and it reset my brain in fundamental ways. Felt like an operating system reinstall.

Overtonwindow 5y ago
Dis you trip while also on other medication? I was on Wellbutrin and Zoloft, but 3 grams didn’t do anything for me. Four grams did, but only mildly, that was enough to have significant therapeutic relief. I suspect depression medications may inhibit the effect?
- at_compile_time 5y ago
  I've read that SSRIs interfere with them. It feels like a pretty cruel irony.
- hobs 5y ago
  After a quick skim https://mind-foundation.org/psychedelic-antidepressant-interactions/ https://mind-foundation.org/psychedelic-antidepressant-inter... is worth reading - in a nutshell I have personally seen this: 1. Someone taking SSRI's and psilocybin finds that the dosage... simply doesnt work. I had one individual who ate up to 8! grams before seeing and feeling things that I would see in normal people at about 1.5. 2. This might be really bad for you! There's some evidence that mixing that level of both drugs might be not good for your liver and might get you into toxic levels, and suggests tapering - I honestly dont suggest tapering your anti-depressants unless you are working with a medical professional because well, suicide. 3. If you really want an undenyable trip, just take some salvia (properly), 15 minutes and many of the same after effects.
- DrBoring 5y ago
  > I suspect depression medications may inhibit the effect? When I was on Wellbutrin, it stopped the mental effect of alcohol. When I imbibed, there was no loss of inhibition normally associated with alcohol use. However, I did still lose physical coordination. Zoloft did not have the same effect. The brain is a crazy thing.
  - tomek_ycomb 5y ago
    I agree 100% brain is a crazy thing. In general I think this is most pronounced even within antidepressants of the same class, with similar binding affinities, some people report limited success with one or the other seemingly similar drug. All this said, wellbutrin is a very different drug than zoloft. It have more dopamine and norepinephrine activity iirc. Also for anyone else, try to avoid alchohol and wellbutrin or take it knowing that your seizure threshold goes down on wellbutrin so its easy to black out and do worse than you realize (also related to the reported effects above)
- hackingthelema 5y ago
  Depends on the antidepressant, but SSRIs like Zoloft do suppress the effect. MAOIs, on the other hand, tend to increase the effect. I'm not sure about Wellbutrin. There's some charts floating around about it on the internet: https://wiki.tripsit.me/wiki/Drug_combinations https://wiki.tripsit.me/wiki/Drug_combinations
  - pmoriarty 5y ago
    Be very, very careful about combining MAOI's with psychedelics (or other drugs). Educate yourself thoroughly on what effect such combinations could have before you even think of doing this. Combining drugs in general is often a very bad idea, and many overdoses and other adverse reactions have been due to this.
- Stevvo 5y ago
  Yes, depression medications inhibit the reuptake of serotonin whilst psychedelics bind to your serotonin receptors.

Dis you trip while also on other medication? I was on Wellbutrin and Zoloft, but 3 grams didn’t do anything for me. Four grams did, but only mildly, that was enough to have significant therapeutic relief. I suspect depression medications may inhibit the effect?

at_compile_time 5y ago
I've read that SSRIs interfere with them. It feels like a pretty cruel irony.
hobs 5y ago
After a quick skim https://mind-foundation.org/psychedelic-antidepressant-interactions/ https://mind-foundation.org/psychedelic-antidepressant-inter... is worth reading - in a nutshell I have personally seen this: 1. Someone taking SSRI's and psilocybin finds that the dosage... simply doesnt work. I had one individual who ate up to 8! grams before seeing and feeling things that I would see in normal people at about 1.5. 2. This might be really bad for you! There's some evidence that mixing that level of both drugs might be not good for your liver and might get you into toxic levels, and suggests tapering - I honestly dont suggest tapering your anti-depressants unless you are working with a medical professional because well, suicide. 3. If you really want an undenyable trip, just take some salvia (properly), 15 minutes and many of the same after effects.
DrBoring 5y ago
> I suspect depression medications may inhibit the effect? When I was on Wellbutrin, it stopped the mental effect of alcohol. When I imbibed, there was no loss of inhibition normally associated with alcohol use. However, I did still lose physical coordination. Zoloft did not have the same effect. The brain is a crazy thing.
- tomek_ycomb 5y ago
  I agree 100% brain is a crazy thing. In general I think this is most pronounced even within antidepressants of the same class, with similar binding affinities, some people report limited success with one or the other seemingly similar drug. All this said, wellbutrin is a very different drug than zoloft. It have more dopamine and norepinephrine activity iirc. Also for anyone else, try to avoid alchohol and wellbutrin or take it knowing that your seizure threshold goes down on wellbutrin so its easy to black out and do worse than you realize (also related to the reported effects above)
hackingthelema 5y ago
Depends on the antidepressant, but SSRIs like Zoloft do suppress the effect. MAOIs, on the other hand, tend to increase the effect. I'm not sure about Wellbutrin. There's some charts floating around about it on the internet: https://wiki.tripsit.me/wiki/Drug_combinations https://wiki.tripsit.me/wiki/Drug_combinations
- pmoriarty 5y ago
  Be very, very careful about combining MAOI's with psychedelics (or other drugs). Educate yourself thoroughly on what effect such combinations could have before you even think of doing this. Combining drugs in general is often a very bad idea, and many overdoses and other adverse reactions have been due to this.
Stevvo 5y ago
Yes, depression medications inhibit the reuptake of serotonin whilst psychedelics bind to your serotonin receptors.