Psilocybin has been in the news lately, but I'd say many drugs that cause a significant, immediate and forceful shift in thinking can work for depression. From

Psilocybin has been in the news lately, but I'd say many drugs that cause a significant, immediate and forceful shift in thinking can work for depression. From my own experience making and taking a simple drug, just experiencing good thoughts once in a while kind of pulls me out of persistent/chronic depression. I know I'm getting better when I start thinking "wow, trying to kill myself was actually horrifying yo!". The trick, imo, is to take something that is guaranteed to make you think happy/different thoughts (not only feel good). Which is why I think there's better options than psychedelics that can cause bad trips, at least for some types of depression. Which is also why cannabis can work but is very hit or miss - it having short or long term negative effects is very likely. Now if only it wasn't so fucking hard and risky to create and use your own medication. Alcohol is perfectly legal and absolutely life destroying. But God forbid you even possess something illegal - they'll make sure you don't end your years of suffering. Oh the Hugh manatee.