Could there be some content in the emails that triggers spam filters? Are the usernames or domain something that might trigger it? Is your server time correct?

Could there be some content in the emails that triggers spam filters? Are the usernames or domain something that might trigger it? Is your server time correct? It might also be that many users have marked emails from the domain as spam (I know of that happening with competitors signing up to newsletters etc. just to mark them as spam).