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It's surprising that with all the regenerative medicine there's nothing too revolutionary? I mean they know fasting helps, along with regular exercise etc. But

It's surprising that with all the regenerative medicine there's nothing too revolutionary? I mean they know fasting helps, along with regular exercise etc. But I'm surprised there's not a specific supplement or whatever that people agree helps prevent aging etc. or some kind of therapy? You think there'd be something found in the last 20 years, people can agree on, that's been helpful to prevent aging? is there something like that?

vmception 5y ago
In this article they are building on top of the technology that lets them turn any cell back into a stem cell, but instead of resetting the cell where it looses its specialized function waiting to be transformed into any cell, they stop short of that and it just continues as a healthier younger cell retaining its current specialized function. This seems to be building on things that were revolutionary already. Might want to read the article. But there is no medicine to take yet. I could see a shot or supplement in the future targeting a variety of cells to halfway deprogram for the youth affect.
miltondts 5y ago
Check some of the compounds that are being investigated here: https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ Fisetin among others seems to have some promise, however how much this will impact lifespan is unknown. Fisetin probably not much, partial reprogramming (OSKM etc) maybe a bit more.
deltaonefour 5y ago
There is. Rapamycin and metformin. Both have anti-aging effects. But experiments to prove this on humans are hard to replicate as it involves studies of humans dying of old age. You'd need probably 20 years to run such a test. So they have shown this for mice and rats. BUT, there are side effects. Also I don't think these things reverse aging, they definitely slow it down though. I know rapamycin specifically works on MTOR which is identical to what happens with fasting. Too much rapamycin though isn't good.

vmception 5y ago

In this article they are building on top of the technology that lets them turn any cell back into a stem cell, but instead of resetting the cell where it looses its specialized function waiting to be transformed into any cell, they stop short of that and it just continues as a healthier younger cell retaining its current specialized function. This seems to be building on things that were revolutionary already. Might want to read the article. But there is no medicine to take yet. I could see a shot or supplement in the future targeting a variety of cells to halfway deprogram for the youth affect.

miltondts 5y ago

Check some of the compounds that are being investigated here: https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ Fisetin among others seems to have some promise, however how much this will impact lifespan is unknown. Fisetin probably not much, partial reprogramming (OSKM etc) maybe a bit more.

deltaonefour 5y ago

There is. Rapamycin and metformin. Both have anti-aging effects. But experiments to prove this on humans are hard to replicate as it involves studies of humans dying of old age. You'd need probably 20 years to run such a test. So they have shown this for mice and rats. BUT, there are side effects. Also I don't think these things reverse aging, they definitely slow it down though. I know rapamycin specifically works on MTOR which is identical to what happens with fasting. Too much rapamycin though isn't good.