Serotonin reuptake inhibitors are as good as placebo against major depression and, as you have noted, unsafe to use for longer periods. Some people find the emo

Serotonin reuptake inhibitors are as good as placebo against major depression and, as you have noted, unsafe to use for longer periods. Some people find the emotional blunting effect of these drugs helpful while waiting for the depression to pass, but this merely suppresses one of the less disabling symptoms and does not counteract the condition. SSRIs are not anti-depressants. Major depression recurred frequently for most of my life and I was suicidal in my 30s. I asked every physician and health professional I could find for advice and was willing to try just about any therapy or treatment. None of them were helpful in the slightest and after a particularly frustrating experience with a useless, hostile, and expensive psychiatrist I gave up on getting any assistance from the health industry. Since no one was willing to help I needed to figure this out for myself. I read everything I could find about depression that was not overtly pseudoscientific or superstitious, including hundreds of anti-depressant drug trials of wildly varying quality and power. The breakthrough was realizing that major depression is not a disease or "mental illness"; it is in fact adaptive behaviour shared by all mammals which has become maladaptive in humans due to our modern environments and societal interactions being so far removed from the ones our species evolved in. Mammals cannot prosper under chronically stressful conditions, e.g. many predators or much stronger rivals in our local environment. Chronic stress from such fears and concerns is what triggers the depression, which alters our behaviour primarily by suppressing dopaminergic pathways. This shuts down normal motivated behaviour like the drive to explore our environment or find a mate and makes us stay at home where we feel safest, recuperating as if sick or injured. This is adaptive because it takes the mammal away from the sources of stress. With environmental stress sources gone the depression will slowly pass, and after a while the mammal is ready to leave its nest, making another attempt at living in its natural environment. Depression has become maladaptive in modern humans because many of our sources of stress are abstract and long-term concerns that cannot be evaded by staying at home in bed: we worry about losing our source of employment, armed conflicts in neighbouring countries, global warming, and how our stock portfolio is doing. Many human disorders (e.g. anxiety) also predispose us to chronic stress and therefore depression. In my case the root cause turned out to be undiagnosed autism spectrum disorder. I can now manage my depression quite well, but I have had to make large sacrifices – like avoiding most normal social interaction – to achieve this. You may be able to find the solutions you seek if you can learn the reasons why you are depressed.