You can't change 1 bit, each base contains 2 bits of information. We can compare each base vs ancestor bases, eg primates and other vertebrates - called conser

You can't change 1 bit, each base contains 2 bits of information. We can compare each base vs ancestor bases, eg primates and other vertebrates - called conservation scores. Some areas are highly conserved, so changing those will probably have worse outcomes than less conserved regions.