Depending on the monitor/laptop combination and their support for USB-C that's not too much of a hassle. For reference, I am using an XPS 13 and a Lenovo P24h.

Depending on the monitor/laptop combination and their support for USB-C that's not too much of a hassle. For reference, I am using an XPS 13 and a Lenovo P24h. All of the peripherals are plugged into the monitor, and when I unpack my laptop, I just plug in a single USB-C cable and I am on my way. Multiple monitors can (supposedly) be daisy-chained as well, although I have not tried this.