what do you mean by "~1 SNP?" one de novo amino acid substitution? or inherited? we have millions of variants. the redundancy of codons - several codons code f

what do you mean by "~1 SNP?" one de novo amino acid substitution? or inherited? we have millions of variants. the redundancy of codons - several codons code for most amino acids, and one-base-pair changes are often synonymous or will code for similarly-charged residues - provides some protection. on the other hand, if you have a mutation in, say, a non-coding intronic splice site, that can really fuck a protein up. I got unlucky there.