3 ms·

Not true at all. So much charming and well intentioned misinformation on this thread; as much as if I were to weigh in on the pros and cons of MariaBD versus P

Not true at all. So much charming and well intentioned misinformation on this thread; as much as if I were to weigh in on the pros and cons of MariaBD versus PostgreSL. Coding sequence is under significantly higher levels of active “purifying” selection than regulatory DNA, and much higher than de novo mutations in repetitive mobile elements that only rare perturb phenotypes.

axg11 5y ago
Single point mutations in regulatory elements such as enhancers have been shown to change the expression levels of multiple genes. These elements are under just as much selective pressure as any coding region.
- asdff 5y ago
  not all noncoding dna is going to be a regulatory element.