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There is still room for improvement though, parts of the Y chromosome are still not there. Is it gonna be GRCh39 or will they change the naming scheme again?
by yread 5y ago
There is still room for improvement though, parts of the Y chromosome are still not there.
Is it gonna be GRCh39 or will they change the naming scheme again?
- mmmrtl 5y ago> [We] have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content for the human reference assembly currently in development. https://www.ncbi.nlm.nih.gov/grc https://www.ncbi.nlm.nih.gov/grc The complete Y chromosome from HG002 was added with v2 (after the paper was written). Probably a patched form of GRCh38 will be made using T2T sequence, but IMO it makes more sense to use T2T-CHM13 as a reference with its single origin instead of a weird chimera, at least until pan-genome graph methods mature.
- robwwilliams 5y agoWe will be killing the archaic concept of a reference genome. All will some be dynamic pangenomic assemblies that grow and flex and branch as more genomes are added.