5 ms·
We'll get another batch of "the human genome is complete" articles when we start publishing graph genomes.
by carbocation 5y ago
We'll get another batch of "the human genome is complete" articles when we start publishing graph genomes.
- robwwilliams 5y agoToo cynical. Pangenomics is a different kettle if fish entirely. It attempts to provide a full view if all types of the more common and rare germline variants in a family, population, species, genus… And can be applied to cancers too.
- carbocation 5y agoAs a human geneticist, I'm not being cynical: I look forward to taking advantage of graph genomes. I'm just making a prediction about what people will say.
- inciampati 5y agoI think those will be saying "we have just begun the sequencing of the human pangenome". The problem is endless. Life on earth is huge.
- robwwilliams 5y agoOne does not “sequence” a pangenome. Pangenomes are single graphical assemblies of many diverse genomes—ideally T2T genomes. Pangenome assemblies will improve accurate health care. Pangenomes allow us to discard the kludge of a “reference” genome.