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Methylation is a metabolic chemical reaction your body does, facilitated by enzymes, that sticks a methyl group onto stuff. There’s different genetic mutations

Methylation is a metabolic chemical reaction your body does, facilitated by enzymes, that sticks a methyl group onto stuff. There’s different genetic mutations for more or less copies or less efficient copies of the relevant enzymes. The idea is some people are genetically very low/poor methylaters so they’re methylation impaired. Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate

celdon25 5y ago
> Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate Other possible treatments are L-Methionine or S-Adenosyl-Methionine (SAMe), as was recommended in my personal case of a deficiency in "methionine adenosyltransferase" (https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetase_enzyme https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetas...). If you are on a concurrent SSRI (as many with this problem tend to need), the L-Methionine is temporarily used in lieu of the SAMe in order to help wean off the SSRI without the risk of Serotonin Syndrome that comes with SAMe + SSRI combination. I'm not a doctor, just someone who has this as a patient.