4 ms·

Have you ever had a methylation profile done? Would highly recommend it. https://www.doctorsdata.com/methylation-profile-plasma/ https://www.doctorsdata.com/me

Have you ever had a methylation profile done? Would highly recommend it. https://www.doctorsdata.com/methylation-profile-plasma/ https://www.doctorsdata.com/methylation-profile-plasma/

barbs 5y ago
What's a methylation profile? I tried reading the link but it seemed quite technical.
- __blockcipher__ 5y ago
  Methylation is a metabolic chemical reaction your body does, facilitated by enzymes, that sticks a methyl group onto stuff. There’s different genetic mutations for more or less copies or less efficient copies of the relevant enzymes. The idea is some people are genetically very low/poor methylaters so they’re methylation impaired. Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate
  - celdon25 5y ago
    > Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate Other possible treatments are L-Methionine or S-Adenosyl-Methionine (SAMe), as was recommended in my personal case of a deficiency in "methionine adenosyltransferase" (https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetase_enzyme https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetas...). If you are on a concurrent SSRI (as many with this problem tend to need), the L-Methionine is temporarily used in lieu of the SAMe in order to help wean off the SSRI without the risk of Serotonin Syndrome that comes with SAMe + SSRI combination. I'm not a doctor, just someone who has this as a patient.
cjbgkagh 5y ago
Not yet, I’ve been going down other paths. I’ll look into it, thx
PragmaticPulp 5y ago
FYI: Most "methylation" tests, books, and treatments are very firmly in the alternative medicine category. Much of it is pseudoscience. It is true that a small subset of people can have a certain set of mutations that has clinical significance, but the alternative medicine community has been hard at work trying to expand this condition to cover far more people than it actually does. One common trick is to perform as many tests as possible, along with as many permutations of those tests (e.g. the various ratios between values). The more tests you conduct, the easier it is to find one that might be out of a specific range and therefore convince the purchaser that the test was worthwhile. If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you). It's also common to claim a test has significance in every medical condition that people might be Googling. The test you linked is guilty of this, claiming to be "Useful for" everything from autism to birth defects to cancer, down syndrome, immune dysfunction, nutritional deficiencies, psychiatric disorders and more. Any test that claims to be relevant to so many different medical conditions is a huge red flag. Save your money. If you're curious, you can read more about how the whole "methylation" and MTHFR alternative medicine got so out of control because one naturopathic author pushed it so hard as an explanation for everything: https://www.mcgill.ca/oss/article/pseudoscience-reviews/genetic-astrology-naturopath-ben-lynch https://www.mcgill.ca/oss/article/pseudoscience-reviews/gene... There's another good article here about why this test isn't really warranted for most people: https://health.clevelandclinic.org/a-genetic-test-you-dont-need/ https://health.clevelandclinic.org/a-genetic-test-you-dont-n...
- celdon25 5y ago
  As someone who personally experienced a rapid and significant resolution of ADHD, fatigue, and other symptoms as a result of a methylation test + methionine supplementation (supervised and recommended by a mainstream medical doctor at my primary care clinic), this is amusing to read. Cue the "but anecdotal experiences aren't valid" hyperbole. > Any test that claims to be relevant to so many different medical conditions is a huge red flag. How much do you understand about DNA methylation? > If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you). Homozygous C677T still affects ~10% of caucasians but isn't sufficient in and of itself to show poor methylation. C677T only shows a predisposition to the problem. So you have it backwards on recommended tests. Since not everyone knows where to find cheap genetic tests, I'll be a good neighbor and recommend Nebula Genomics + Promethease (with the exported raw data). Stay away from 23andme.

Have you ever had a methylation profile done? Would highly recommend it. https://www.doctorsdata.com/methylation-profile-plasma/ https://www.doctorsdata.com/methylation-profile-plasma/

barbs 5y ago

What's a methylation profile? I tried reading the link but it seemed quite technical.

__blockcipher__ 5y ago
Methylation is a metabolic chemical reaction your body does, facilitated by enzymes, that sticks a methyl group onto stuff. There’s different genetic mutations for more or less copies or less efficient copies of the relevant enzymes. The idea is some people are genetically very low/poor methylaters so they’re methylation impaired. Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate
- celdon25 5y ago
  > Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate Other possible treatments are L-Methionine or S-Adenosyl-Methionine (SAMe), as was recommended in my personal case of a deficiency in "methionine adenosyltransferase" (https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetase_enzyme https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetas...). If you are on a concurrent SSRI (as many with this problem tend to need), the L-Methionine is temporarily used in lieu of the SAMe in order to help wean off the SSRI without the risk of Serotonin Syndrome that comes with SAMe + SSRI combination. I'm not a doctor, just someone who has this as a patient.

cjbgkagh 5y ago

Not yet, I’ve been going down other paths. I’ll look into it, thx

PragmaticPulp 5y ago

FYI: Most "methylation" tests, books, and treatments are very firmly in the alternative medicine category. Much of it is pseudoscience. It is true that a small subset of people can have a certain set of mutations that has clinical significance, but the alternative medicine community has been hard at work trying to expand this condition to cover far more people than it actually does. One common trick is to perform as many tests as possible, along with as many permutations of those tests (e.g. the various ratios between values). The more tests you conduct, the easier it is to find one that might be out of a specific range and therefore convince the purchaser that the test was worthwhile. If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you). It's also common to claim a test has significance in every medical condition that people might be Googling. The test you linked is guilty of this, claiming to be "Useful for" everything from autism to birth defects to cancer, down syndrome, immune dysfunction, nutritional deficiencies, psychiatric disorders and more. Any test that claims to be relevant to so many different medical conditions is a huge red flag. Save your money. If you're curious, you can read more about how the whole "methylation" and MTHFR alternative medicine got so out of control because one naturopathic author pushed it so hard as an explanation for everything: https://www.mcgill.ca/oss/article/pseudoscience-reviews/genetic-astrology-naturopath-ben-lynch https://www.mcgill.ca/oss/article/pseudoscience-reviews/gene... There's another good article here about why this test isn't really warranted for most people: https://health.clevelandclinic.org/a-genetic-test-you-dont-need/ https://health.clevelandclinic.org/a-genetic-test-you-dont-n...

celdon25 5y ago
As someone who personally experienced a rapid and significant resolution of ADHD, fatigue, and other symptoms as a result of a methylation test + methionine supplementation (supervised and recommended by a mainstream medical doctor at my primary care clinic), this is amusing to read. Cue the "but anecdotal experiences aren't valid" hyperbole. > Any test that claims to be relevant to so many different medical conditions is a huge red flag. How much do you understand about DNA methylation? > If you really wanted to test something, you'd skip this test and get a cheap genetic test to see your MTHFR variant (note: heterozygous is fine, no matter what the naturopaths try to tell you). Homozygous C677T still affects ~10% of caucasians but isn't sufficient in and of itself to show poor methylation. C677T only shows a predisposition to the problem. So you have it backwards on recommended tests. Since not everyone knows where to find cheap genetic tests, I'll be a good neighbor and recommend Nebula Genomics + Promethease (with the exported raw data). Stay away from 23andme.